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reinforcement of epithelial barrier integrity (Si et al., 2025)

Certain antihistamines notably cimetidine and promethazine have been shown to actually reduce DAO activity with prolonged use, potentially worsening the underlying deficiency over time

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[3] Whilst Mounjaro itself does not directly cause B12 deficiency, the dietary changes and reduced food intake associated with its use could theoretically contribute to suboptimal nutrient intake