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These burns, induced by controlled exposure to direct flame for 5 or 7 seconds, created substantial injuries requiring significant healing responses

With regard to Nrf2 activators, such as sulforaphane and bardoxolone, the majority of evidence is currently derived from in vitro experiments or animal models of oxidative stress-related disorders, including osteoarthritis and IDD (72)

J Biol Chem 277:3916339168 MacDonald MJ, Efendic S, Ostenson CG (1996) Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat

Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease