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Here too, inhibition of MCU-dependent presynaptic Ca 2+ uptake caused increased presynaptic cytoplasmic Ca 2+ levels and negatively affected short-term synaptic plasticity [55]

Two of the peptides most often caught up in these discussions are covered in their own summaries: BPC-157, a synthetic peptide studied mostly in animals, and ipamorelin, a growth-hormone secretagogue

This different mechanism may explain why combining cagrilintide with GLP-1 therapy (CagriSema) produces greater weight loss than either alone

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