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doi: 10.1080/15592324.2020.1832373 23 KleiberA.DuanQ.JansenK.Verena JunkerL.KammererB.RennenbergH.et al

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When the PI3K-AKT-mTOR signaling pathway is activated, mTORC1 can inhibit ferroptosis by upregulating the expression of SREBP1(Wu et al., 2021

These modified proteins can be taken up by antigen-presenting cells (APCs), processed, and presented to T cells, leading to the activation of autoreactive T cells and the production of autoantibodies