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A study experimented VC in combination with each of eribulin mesylate, tamoxifen, fulvestrant, and trastuzumab on a variety of breast cancer cell lines (MCF7, SK-BR3, MDA-MB-231, and breast epithelial cells MCF10A), have shown that high-dose VC with each of those anti-cancer drugs had decreased the cell viability of cancer cells more comprehensively than high-dose of VC or chemotherapy alone (90)

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PDB 5F07 was used in molecular replacement to determine the starting phases for refinement with anisotropic B-factors and hydrogen atoms using MOLREP 67

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