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Vitamin B12 has a good safety profile, but some important considerations include rare hypersensitivity reactions (including anaphylaxis) with injections, potential hypokalaemia during early treatment of severe deficiency, and possible cutaneous reactions

Comparatively, folate deficiency is notably prevalent in cases of depression, occurring twice as often as vitamin B12 deficiencies (64)

Safety assessments included treatment-emergent adverse events (AEs), vital signs (BP and HR), bodyweight, physical examinations and laboratory parameters