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Nicotine in diseases Smoking inserts a high amount of xenobiotics, which in turn can alkylate DNA, activate specific (anti)inflammatory signals, and oxidative stress in active smokers and also second-hand smokers [167, 168]

However, they warn that smokers keep cigarette smoke longer in the lungs, increase the speed and depth of inhalation, and increase the number of cigarettes as well when smoking low-tar or low-nicotine cigarettes, in order to increase the nicotine dose

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By adjusting for body mass index and education, estimates of drinks per week remained consistent in multivariate MR analyses, while alcohol intake frequency became non-significant