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Even safety data on TB-500 (synthetic TB4) is relatively scarce, with only a few studies reporting the potential side effects of its systemic application: In a 2010 study in 10 participants, TB4 caused occasional mild to moderate symptoms like headache and dizziness but no serious reactions or toxicities, even at doses up to 1260mg, administered daily for up to two weeks

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Goal: Inhibit NNMT to raise intracellular NAD+ and activate SIRT1, theorized to support fat metabolism and preserve lean mass effects reported in animal and cell studies, not established in humans [1] [5]