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From claims that the candy would make children smoke actual cigarettes (which wasn't that far off, considering later research) or turn them into alcoholics, candy cigarettes were treated as a threat to children's well-being

In some cases, e-cigarettes stimulate the production of ROS in alveolar macrophages, causing lung epithelial damage and neutrophil influx at injury sites, resulting in aggravated inflammation, mucus production, and destruction of alveolar cells, leading to airway obstruction [53]

[14] Systemic disease [edit] Aphthous-like ulceration may occur in association with several systemic disorders (see table)