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Chapter 411

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Composition of the Cag Research Vial VITALA Cag is a single-compound research vial, giving researchers a clean and precisely dosed tool for studying this long-acting amylin analogue in isolation or as part of a broader combination research protocol

B 0 is the baseline motor score, E max is the maximum inhibitory effect, Cp is the apomorphine plasma concentration predicted by the PK model, Ce is the drug concentration at the site of action, EC 50 is the drug concentration that causes 50% of the maximum effect, g is the Hills sigmoid coefficient, and k e0 is the first-order plasma-effect-site equilibration rate constant