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Our findings, which utilize a novel CSMN reporter line with TDP-43 pathology, not only reveal the presence of metabolomic defects at an early stage of the disease, but also suggest that proper modulation of metabolomic imbalance could offer therapeutic strategies to improve the integrity of mitochondria, and thus the health of diseased UMNs

After pooling the fractions containing pure 3,4- cis -leucocyanidin ( 6 ), MOPSO was added to a final concentration of 10 mM, the pH was set to 6.2 using 5 N NaOH and the pooled fractions were rotary-evaporated to a concentration of 7 mM of 3,4- cis -leucocyanidin ( 6 ), quantified by HPLC-UV (280 nm) with an external calibration curve with 3,4- trans -leucocyanidin ( 14 )

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Son Kullanma Tarihi: 30.02.2028 899,00 TL 1.650,00 TL 751.00 TL ndirim