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Testicular dysfunction in diabetes is caused by spermatogenesis, atrophy of the seminiferous tubules, decreased tubular diameter, cell shrinkage, and germ cell death []

The onset of action can vary based on individual factors such as metabolism and rectal conditions

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However, other researchers have argued that controversial issues exist because GPNA also inhibits other glutamine transporters, such as SLC38A1, and V-9302 is effective even in SLC1A5 knockout models 206,207