Given that MTX is more effective against dividing cells because of its effect on the nucleotide synthesis, we also examined correlations between metabolites concentrations and cell proliferation rate, as this could be a confounding factor (proliferation curves for doubling time determination are in Supplemental Figure 5 )
This mineral is commonly low in the typical Western diet that is deficient in good quality organ meats, seafood and nuts such as Brazil nuts, which are the richest source of selenium
Previous study proved the promising protective effect of UMB against MTX-induced intestinal damage by markedly improved oxidant/antioxidant status, as shown by the parallel decrease in MDA contents and the elevation of Nrf2, SOD, HO-1, and GSH levels
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