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Plain sterile water is not preservative-free bacteriostatic once the vial seal is broken, it is susceptible to microbial contamination and should only be used for single-draw applications

On the other hand, in another study of PSD, a high dose of caffeine impairs memory and leads to an anxiogenic and depressive-like behavior in the hole board and elevated plus maze tests, and social interaction and locomotor activity, respectively, also increased pro-inflammatory cytokines such as TNF-alpha and IL-6 [37]

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