Background on the PACT Act As part of the Consolidated Appropriations Act, 2021, in the most recent COVID-19 relief bill signed into law on December 27, 2020, Congress amended the Prevent All Cigarette Trafficking (PACT) Act to apply to e-cigarettes and all vaping products
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These compounds serve different functions in plants, such as being hormones (e.g., gibberellins and abscisic acid), photosynthetic pigments (e.g., phytol and carotenoids), electron transporters (e.g., ubiquinone and plastoquinone), and structural components of membranes (e.g., phytosterols)

These covariates included HDL (high-density lipoprotein) cholesterol, LDL (low-density lipoprotein) cholesterol, HDL cholesterol ratio, triglycerides, sitting diastolic and systolic blood pressure (mean of three measures), history of high blood pressure, history of stroke or cardiovascular disease, Fazekas score, FEV1, alcohol units per week, hemoglobin A1c, diagnosis of diabetes, depression score from HADS, age-11 IQ and SES: Cortical thickness= b 0 Intercept+ b 1 Gender+ b 2 Exact_Age_At_Scanning+ b 3 PackYears + b 4 HDL_Cholesterol+ b 5 LDL_Cholesterol+ b 6 HDL_Cholesterol_Ratio+ b 7 Triglycerides+ b 8 Diastolic_Pressure+ b 9 Systolic_Pressure+ b 10 HighBloodPressureHistory + b 11 Stroke_History+ b 12 Fazekas_Score + b 13 Cardiovascular_Disease_History + b 14 FEV1+ b 15 Weekly_Alcohol_Units+ b 16 Hemoglobin_A1C+ b 17 Diabetes_Diagnosis + b 18 HADS+ b 19 Age-11_IQ+ b 20 SES+error To assess whether the association between smoking and cortical thickness varied as a function of the age of starting smoking, Models 2 and 3 were retested after including smoking starting age' and the smoking starting age' by pack-years' interaction term
