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One study showed that AMs from bronchoalveolar lavage fluid (BALF) of smokers and e-cigarette users are phenotypically distinct, with macrophages from e-cigarette vapers having elevated inducible nitric oxide synthase (marker for M1 macrophages) expression and reduced CD301a (marker for M2 macrophages) expression compared with nonsmokers or smokers(29)

More studies needed The study authors say that cadmiums association with higher mortality from flu and pneumonia needs to be verified in other populations and also studied specifically in COVID-19 patients