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Material and methods Cell culture HeLa (ATCC Number: CCL-2) and SHSY-5Y (ATCC Number: CRL-2266) cells, STR profiled and free from any contamination, were sourced from National Center for Cell Science repository

GuillemetteC.2003Pharmacogenomics of human UDP-glucuronosyltransferase enzymes.33(2003),136158,0147-0269X 41

All samples were collected with the patients written informed consent and approval from the Sixth Affiliated Hospital of Sun Yat-sen University Review Board (ethics code: 2021ZSLYEC-100)

Moreover, we emphasize GSH system-related ferroptosis in cardiac injury events and comprehensively summarize strategies for GSH system activation