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Utility of human leukocyte antigen-B*58: 01 genotyping and patient outcomes

If further clarification is required, please contact the clinic where Dr Knight or a member of our team will be able to offer assistance

The core direction of future research should focus on directly verifying the causal relationship between local joint ferroptosis and gut microbiota dysbiosis through germ-free OA mouse models, fecal microbiota transplantation experiments, or conditional knockout models of key genes for chondrocyte-specific ferroptosis (such as GPX4 and ACSL4)