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In the presence of VEGF, MDSCs can create a pro-angiogenic milieu within the tumors by secreting angiogenic factors including CCL2, CXCL8, CXCL2, IL-1, ANGPT1, ANGPT2, and GM-CSF [251, 252]

In addition, it would make payment and policy changes for inpatient hospital services provided by long-term care hospitals (LTCHs) under the long-term care hospital prospective payment system (LTCH PPS)

Treatment of such events usually involves discontinuation of DPA (and the use of another anti-copper drug), but in more severe cases, temporary treatment with steroids is suggested to reduce the autoimmune response and clinical symptoms associated with a DPA-related adverse event [160]

Finally, the review will discuss therapeutic strategies targeting GPX4 and ferroptosis, including pharmacological and gene therapies, and analyze the main challenges in this field and potential future research directions