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Furthermore, it has also been demonstrated that hypoxia-driven CSC enrichment in breast cancer originates from a dedifferentiation process and that hypoxia-inducible factors (HIFs) are essential for chemotherapy resistance in breast CSCs (Iriondo et al., 2015)

10.1196/annals.1375.034 [DOI] [PubMed] [Google Scholar] 113.Bartalena L, Fatourechi V

This review provides a comprehensive summary of different mechanisms involved in hyperpigmentation and gives a clear guide to topical active ingredients with clinical evidence