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Collectively, these results confirm that disruption of the glucagon receptor in mice significantly enhances glucagon expression and glucagon granule populations in cells

239 In addition, high concentrations of calcium ions also indirectly down-regulated Mfn1 and Mfn2, further inhibited mitochondrial fusion, that ultimately promoted mitochondrial fission in senescent cells

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Positron emission tomography (PET) has identified lower GABAA receptor levels in the limbic system, including the nucleus accumbens, amygdala, and hippocampus, in high-functioning adult ASD patients compared to healthy controls (55, 127)