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doi: 10.1186/s12879-024-10435-8 109 ElfmannC.StlkeJ

Testosterone replacement therapy (TRT) can reduce sperm production and temporarily impact fertility in some men, making it important to discuss family planning goals with a healthcare provider before starting treatment

However, there are significant precautions and concerns regarding its use, particularly related to tumor growth and the lack of rigorous human studies

Recently, increased IGF-I expression was reported in obese children with non-alcoholic fatty liver disease (NAFLD) and it was combined with upregulation of IGF1R (96), not expressed in the normal liver but involved in liver repair, such as after liver resection in a mouse model (97)