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If the reason is less clear, the care team may recommend review of symptoms, outside records, or broader follow-up before turning B12 into a repeating plan

There are also supportive conceptual points providing a larger therapeutical background [24,25]

Extended data figures and tables Extended Data Figure 1 The iChip

Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans