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The study demonstrated elevated levels of pro-inflammatory cytokines, such as IL-1 and TNF-, in the brains of CKD mice, indicating that gut-derived signals play a central role in mediating neuroinflammation in CKD (Andrade-Oliveira et al., 2015)

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The enzyme cystathionine--synthase (CBS) that catalyzes the first step in the transsulfuration pathway is highly expressed in liver cells but not highly expressed in peripheral cells, so it is not surprising that the liver is the major producer of GSH, much of which is exported to the plasma and enzymatically broken down to cysteinylglycine and cyst(e)ine that is subsequently taken up by other cells for GSH synthesis