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Increasing evidence indicates that ApoE isoforms modulate synaptic function in an isoform-specific manner

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These results are supported by a recent randomized placebo controlled trial, which demonstrated that a 6-week sulforaphane intervention (30 mg/day) safely improved depressive symptoms, as measured by the Hamilton Rating Scale for Depression, in 66 participants with a history of a cardiac procedure and presence of mild to moderate depression (Ghazizadeh-Hashemi et al., 2021)

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doi: 10.1016/j.ejps.2012.03.010 209 HassanAASayyahSG

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