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Because research-market material is sold outside any approved supply chain, its identity and purity are unverified: trial data describe a characterized study drug, not the contents of an arbitrary vial, so a batch certificate of analysis is the minimum a research setting should require

Under basal conditions, NRF2 is kept at a low cellular concentration by the activity of Keap1, its major regulator, keeping the expression of NRF2-regulated genes at low levels in order to preserve the correct redox homeostasis [152]