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Additionally, bronchopulmonary dysplasia, in which bombesins have been implicated [205], is considered a risk factor for asthma [206]

Molecular docking and biochemical studies indicate that luteolin interacts with estrogen receptor- (ER-) and estrogen receptor- (ER-) within their ligand-binding domains ( At the receptor level, luteolins differential binding to ER- and ER- allows it to function as a weak phytoestrogenic selective estrogen receptor modulator (SERM), displaying partial agonist activity in estrogen-deficient environments and antagonistic effects under estrogen-excess conditions ( 5.6 Integrated cross-talk and systems-level regulation The pathways described above operate as an integrated signaling network rather than isolated linear cascades

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X-YM and H-HZ revised the manuscript