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Gruchlik A., Jurzak M., Chodurek E., Dzierzewicz Z

10.1016/j.pscychresns.2011.06.014 Psychiatry Res

79 In a phase 3 clinical trial (NCT02666664), Bempedoic acid significantly reduced low-density lipoprotein cholesterol (LDL-C) levels

The apolipoprotein E4 genotype contributes to the abnormal accumulation of lipid droplets (LD) in microglia and the formation of neurotoxic LD-accumulating microglia, which are capable of directly inducing neuronal Tau phosphorylation and apoptosis, and the degree of LD accumulation is positively correlated with the severity of cognitive decline and pathology [148]