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Another proposed mechanism involves the regulation of inflammatory cascades

JAMA Netw Open

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome

Furthermore, the trajectory of the weight loss curves suggested that at 48 weeks the plateau of weight was not yet reached and all the participants in the 8 and 12 mg had a weight reduction of 5% or more, which is currently the minimum threshold for efficacy [64]