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Statistical analysis The avoidance and escape analyses of the ETM data were performed using repeated measures ANOVA, considering the treatment (RC, TFC or control) as the independent factor and the trial (baseline, avoidance 1 and 2 or escape 13) as the dependent factor

However, significant dose relationship was found with smokers of 40 pack-years having a significantly reduced risk of papillary thyroid cancer compared to those who smoked less.[] Four possible biological pathways explain the protective effect of tobacco on thyroid cancer