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Recent review studies have documented that human ApoE genotypes can be classified into six major types based on allelic variations: three homozygous genotypes (ApoE2/2, ApoE3/3, and ApoE4/4) and three heterozygous genotypes (ApoE2/3, ApoE2/4, and ApoE3/4) (Yamazaki et al., 2019

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