Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]
A pivotal study (Yano et al., Cell, 2015) showed that the microbiota influence the serotonergic system through an entire constellation of metabolites many produced by spore-forming Clostridia, the same group known for butyrate and broad gut-supportive functions
In rheumatoid arthritis, the cells are under so much stress that their main protective shield, glutathione (GSH) gets worn down, and oxidative stress damages the mitochondria and the DNA, leading to cell death
It helps support heart health and maintains healthy cholesterol