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Indeed, the mechanisms involved in E2-mediated proliferation are associated with the inhibition of the tumor suppressor protein, p53, which, in turn, generates the downstream activation of cyclin-dependent kinases (CDKs) and, consequently, the release of the retinoblastoma protein (Rb) that promote the progression of the cell cycle by activating diverse transcription factors ( On the other hand, E2 is also involved in the differentiation of diverse types of normal tissues, being critical to the generation of lobular-alveolar cells and the development of galactophorous ducts ( Finally, the pro-survival effects of estrogens have been demonstrated in diverse cell types, including germ cells from human testes (Pentikinen et al., 2000), breast cancer cells (Weldon et al., 2004

doi: 10.1186/1471-2377-12-11 122 CastellazziMFerriCTecillaGHussACrocianiPDesinaGet al

polymer nanomaterials have the advantages of surface modification to achieve multifunctionality, integrating multiple response mechanisms, enhancing drug stability, etc., and some of the materials also have direct antimicrobial activity

The effectiveness of curcumin in treating oral mucositis related to radiation and chemotherapy: A systematic review