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The immunoreactivity for acrolein adducts was markedly increased in the Aldh2*2 KI homozygous mice at 60, 120 min, and 24 h compared with the WT mice, with an accumulation of the acrolein adducts in the necrotic areas

This architecture creates an extraordinarily high binding affinity (pK = 16.44), roughly 10 million times stronger than other tripeptides and comparable to albumins copper binding

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