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Conversely, depression can undermine self-care behaviors that are necessary for effective diabetes management, such as regular medication adherence, appropriate dietary choices, and consistent physical activity [30, 33]

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Changes to the microbial phyla and genera observed in the 5A-1MQ-treated group switched from WD to LD could have been driven by additive, synergistic, or independent mechanisms relative to those induced by diet switch alone, which could not be determined with the current study design that lacked a group treated with 5A-1MQ and maintained on WD

Copper is an essential trace element crucial for many enzymatic reactions and plays a key role in collagen and elastin synthesis, as well as antioxidant defense