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*Correspondence: Ngiap Chuan Tan, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Isolation of primary hepatocytes Primary hepatocytes were isolated from mice, following a previously described protocol ( Cell cytotoxicity assay and treatment Primary hepatocytes were seeded into 96-well plates (100 L per well, 1 10 4 cells/well)