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A 2019 meta-analysis of 15 studies (N=575) found no adverse effect on glomerular filtration rate in healthy individuals taking creatine for up to five years 4

In a systematic review of 129359 patients from 1958 to 2021, the annual rate of decline in GFR ranged from 0.37 to 1.07 mL/min/1.73 m2/year in healthy adults without hypertension ( Under normal circumstances, renal vasodilation induces a noteworthy elevation in renal blood flow and the GFR, indicating the renal hemodynamic and functional reserves capacity

Gastrointestinal Conditions: Disorders like Crohn's disease, celiac disease, or atrophic gastritis can impair absorption