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While earlier studies were limited by crude exposure assessments and lack of chronobiological context (e.g., individual chronotype, sleep quality), newer cohorts are integrating objective measurements such as actigraphy, light sensors, and sleep diaries 28

The focus is on substances that could have caused or contributed to the accident

It exists naturally in human plasma, saliva, and urine with plasma concentrations averaging ~200 ng/mL at age 20 but declining to ~80 ng/mL by age 60

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