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4 Mechanism of probiotics inhibiting Helicobacter pylori 4.1 Competitive exclusion Helicobacter pylori colonizes the gastric mucosa by utilizing adhesion factors, such as outer membrane proteins (OMP)

A hydrogen-bond donor is a covalent bond, DH, where D is a highly electronegative atom, such as N, O, or F

Beyond demonstrating efficacy in clinical trials, healthcare stakeholders increasingly seek evidence on comparative effectiveness, long-term outcomes, quality of life, treatment pathways, and healthcare resource utilization in routine clinical practice

Current studies mainly focus on combinations with dietary control, exercise, and other weightloss agents, aiming to enhance efficacy and reduce side effects