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Another study assessing vascular pathomechanisms indicated a 10 to 20-fold lower effect of IQOS compared to CS on the adhesion of monocytic cells on human coronary arterial endothelial cells (a surrogate of atherogenesis) 66

In addition, smokers tend to have continuous bad breath, a disease that is referred to as halitosis, because of the tar and nicotine contained in cigarettes

Esophageal Muscles : As with the lower esophageal sphincter, nicotine can also relax the smooth muscle that lines the entire length of the esophagus

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