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Pemetrexed-induced hyperpigmentation of the skin

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The results have been striking: GHK-Cu has been shown to modulate the expression of more than 4,000 human genes, with the net effect being a return toward expression patterns associated with younger, healthier tissue.6 The pathways most consistently affected include antioxidant defense (upregulation of catalase, superoxide dismutase, and glutathione synthesis), DNA damage repair, extracellular matrix remodeling, and anti-inflammatory signaling

To determine the MFC, the contents of the wells corresponding to MIC values were sub-cultured onto agar plates and further incubated at 37 C for 24 hours