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To this end, we propose strategies such as advancing clinical trials and further exploring large animal models, which will help bridge the gap between preclinical findings and human therapeutic applications

Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes

However, patients with some types of chronic liver disease also experience improvement after prolonged use of silymarin

At the same time, it improves the ability to absorb iron/glucose and develops resistance to azoles, helping it efficiently adapts to the hosts nutrient-limited microenvironment, and further strengthening its pathogenicity (Pentland et al., 2021)