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Over time, the LES may begin to fail, leading to acid and chemical damage to the esophagus, a condition called gastroesophageal reflux disease (GERD)

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The NIH Drug Interaction Database resource and FDA drug interaction guidance provide frameworks for assessing such risks, but BPC-157 has not been characterized in the in vitro assay battery (CYP enzyme inhibition, P-glycoprotein) that would populate those databases

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