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Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

10.3390/cells8020090 Cells 63 MahrooA.BuckM

Studies conducted in both laboratory settings ( in vitro ) and living organisms ( in vivo ) have provided evidence that certain isoforms of vitamin E, particularly tocotrienols, possess the capability to hinder the angiogenesis process (113)

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