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In a 48-week Phase 2 obesity trial, participants on the 12mg dose recorded a mean body-weight reduction of 24.2%, versus 2.1% on placebo[1]. 83% of that group lost 15% or more of their body weight, and 93% lost at least 10%[1]

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To measure the biochemical parameters, the tissues were perfused with a phosphate-buffered saline (PBS) solution (pH 7.4) containing 0.16 mg/ml heparin at the time of measurement

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