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After NSAIDs or insulin overdose or cuprizone (a neurotoxin that induces multiple sclerosis like lesion in rat model) or large bowel resection, encephalopathies were attenuated along with gastrointestinal, liver and vascular injuries

However, many current studies are primarily focused on improving the pharmacodynamic and pharmacokinetic properties of copper, while data on copper-induced dermal toxicity remain limited

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