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Among these, TNF- production by CGCs can increase senescence of mouse oocytes after ovulation, which may be the cause of oocyte quality decline (106)

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Similarly, HCT116 cells treated with the pan-Raf kinase inhibitor AZ628 (~100-fold higher than the IC 50 ) also yielded a small percentage of DTPs, amounting to ~0.70% of the starting population ( Figures 1B, D, E )

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