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Upon binding to IGF-1R, the peptide initiates multiple intracellular signaling cascades, including the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway, which regulates protein synthesis and cell growth, and the mitogen-activated protein kinase (MAPK) pathway, which controls cell proliferation and survival

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Histochem Cell Biol 147(4):497510 Taati M, Alirezaei M, Moshkatalsadat MH, Rasoulian B, Moghadasi M, Sheikhzadeh F, Sokhtezari A (2011) Protective effects of Ziziphus jujuba fruit extract against ethanol-induced hippocampal oxidative stress and spatial memory impairment in rats