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Neurobiological trait abnormalities in bipolar disorder

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Study selection This review aimed to synthesize evidence from clinical trials examining the role of opioid peptides in ASD and the potential impact of GFCF dietary interventions on opioid peptide concentrations in individuals with ASD

To test the possible increase in potency of the two drugs when given simultaneously, we injected a total volume of 4 ml of combined doses of L838,417 and CLP257 in a fixed dose ratio of \([{\mathrm{L 838,417]/[{\mathrm{CLP 257]\) = 1:55, given the relative EC50s of the two drugs calculated from the respective dose response curves with a priori assumption on the collapse at high doses of L838,417 (Fig