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Stimulates new blood vessel growth to improve nutrient delivery to injured tissues through VEGFR2 pathway activation Enhances fibroblast activity and collagen synthesis for stronger tissue repair and improved structural integrity Increases GH receptor expression making tissues more responsive to natural repair signals Modulates inflammatory response to reduce pain and prevent excessive tissue damage from prolonged inflammation Cell migration represents another critical mechanism

Without a systematic framework, researchers risk wasting time, money, and emotional energy on poorly designed protocols that produce ambiguous results

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10.1016/s0928-4257(99)00119-9 112 SikiricP.MikusD.SeiwerthS.GrabarevicZ.RucmanR.PetekM.et al (1997b)